Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study
An erratum to this article was published (Cardiovasc Diabetol, 9 Jun 2025 ↗)
Main finding · All-cause mortalityResult — go to the resultHazard ratio 1.26 95% CI 1.09–1.45Authors' conclusion
A significant linear association was observed between higher TyG index and increased all-cause mortality at 30, 90, and 365 days in critically ill patients with AF. This underscores the role of the TyG index as a key prognostic indicator for risk stratification and management in intensive care.
Study context
- Population
- Critically ill patients with atrial fibrillation (AF) in the Medical Information Mart for Intensive Care IV (MIMIC-IV) database
- Participants
- 1,473 patients
- Exposure
- Higher vs lower triglyceride-glucose (TyG) index
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsMIMIC-IV database, TyG index tertiles, multivariate Cox proportional hazards regression, restricted cubic splines
- MIMIC-IV database
- TyG index tertiles
- Multivariate Cox proportional hazards regression
- Restricted cubic splines
Main finding
All-cause mortality
Hazard ratio
1.26
95% CI 1.09–1.45
P = 0.002
Highervs lower TyG index
HR 1.26 (95% CI 1.09–1.45); P = 0.002
As reported in the abstract
- 30-day all-cause mortality rate, whole cohort
- 26.8%
Observational data: associations, not effects.
Secondary outcomes
All-cause mortality · 90 days
| HR (95% CI) | P value | ||
|---|---|---|---|
| TyG indexMultivariate Cox analysis | 1.27 (1.11–1.45) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
All-cause mortality · 365 days
| HR (95% CI) | P value | ||
|---|---|---|---|
| TyG indexMultivariate Cox analysis | 1.24 (1.10–1.40) | P < 0.001 | |
| 0.512Hazard ratio (log scale) |
- All-cause mortality — 90-day all-cause mortality rate, whole cohort
- 33.3%
- All-cause mortality — 365-day all-cause mortality rate, whole cohort
- 41.1%
Shape of association and survival by tertile
- Restricted cubic splines: positive linear association between TyG index and mortality risk
- Kaplan-Meier: significant survival disparities across TyG index tertiles
Original publication
Association between triglyceride–glucose index and mortality in critically ill patients with atrial fibrillation: a retrospective cohort study. Cardiovasc Diabetol. Published 24 March 2025. doi:10.
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