Bone Marrow Adiposity Assessed by High-resolution Peripheral Quantitative Computed Tomography (HRpQCT) Is Related to Fracture Risk and Bone Mineral Density in Older Swedish Women
Authors' conclusion
Higher BMFF is associated with lower BMD and higher fracture risk in older women.
Study context
- Population
- Women aged 75 to 80 years from the SUPERB cohort, included March 2013–May 2016
- Participants
- 2,984 women
- Exposure
- Higher vs lower bone marrow fat fraction (BMFF), assessed by HRpQCT
- Outcome
- Incident fractures (MOF, any, hip, vertebral) by BMFF
- Follow-up
- Median 7.3 years
Main finding
As reported in the abstract
Fracture risk per SD higher BMFF
MOF, HR
1.24 (1.15-1.34) (95% CI)
Any fracture, HR
1.20 (1.12-1.28) (95% CI)
Hip fracture, HR
1.22 (1.06-1.40) (95% CI)
Vertebral fracture, HR
1.24 (1.12-1.38) (95% CI)
Observational data: associations, not effects.
Further findings
Correlation of BMFF with BMI and hip bone mineral density (BMD)
- BMI
- r = −0.21, P < .001
- Hip BMD
- r = −0.50, P < .001
Mediation by femoral neck BMD
- A significant proportion of the associations was mediated by femoral neck BMD
Original publication
Bone Marrow Adiposity Assessed by HRpQCT Is Related to Fracture Risk and Bone Mineral Density in Older Swedish Women. J Clin Endocrinol Metab. Published 3 April 2025. doi:10.
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