Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis
Pooled result · Bone marrow PDFFResult — go to the resultMD 11.04 95% CI 9.17–12.92Authors' conclusion
PDFF measurement via MRI shows potential as an osteoporosis biomarker and may serve as a risk factor for osteoporosis.
Study context
- Population
- Patients with bone marrow proton-density fat fraction (PDFF) measured by multi-echo chemical shift-encoded MRI; Cochrane, PubMed, EMBASE and Web of Science up to December 2023
- Participants
- 1,495 patients14 studies
- Comparison
- Bone marrow PDFF in osteoporosis/osteopenia vs normal controls
- Outcome
- PDFF values (osteoporosis/osteopenia vs normal control)
Methodological detailstwo independent researchers, Cochrane risk of bias tool and Agency for Healthcare Research and Quality (AHRQ) checklist, subgroup analyses
- Two independent researchers
- Cochrane risk of bias tool and AHRQ checklist
- Subgroup analyses
Pooled result
Bone marrow PDFF
MD
11.04
95% CI 9.17–12.92
P < 0.00001
Osteoporosis/osteopeniavs Normal control
MD 11.04 (95% CI 9.17–12.92); P < 0.00001
As reported in the abstract
Further pooled results
Subgroup analyses (diagnostic methods, gender, echo length)
- Diagnostic methods, gender and echo length did not significantly impact the PDFF-osteoporosis association
Original publication
Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis. Osteoporos Int. Published 12 August 2024. doi:10.
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