Prevalence and relative risk of fractures and osteoporosis in patients with ankylosing spondylitis: a systematic review and meta-analysis
Authors' conclusion
AS significantly increases the risk of fractures and osteoporosis in patients.
Study context
- Population
- Patients with Ankylosing Spondylitis (AS); epidemiological studies on risk factors or prevalence of fractures and osteoporosis (PubMed, Embase, Cochrane Library, Web of Science, to October 10, 2024)28 studies
- Outcome
- Prevalence of fractures and osteoporosis in AS and associated risk factors
Methodological detailsfixed- or random-effects models, subgroup and sensitivity analyses
- Fixed- or random-effects models
- Subgroup and sensitivity analyses
Pooled result
As reported in the abstract
Prevalence in AS
Overall fracture prevalence
13%
95% CI 9%–17%
Vertebral fracture prevalence
14%
95% CI 9%–19%
Osteoporosis prevalence
14%
95% CI 10%–19%
Further pooled results
Association of AS with fractures
- Vertebral fractures, OR
- 2.26 (95% CI: 1.70-3.00)
- Non-vertebral fractures, OR
- 1.24 (95% CI: 1.02-1.50)
AS assessment indices and fracture risk
- BASDAI, OR
- 1.05 (95% CI: 1.02-1.08)
- mSASSS, OR
- 1.04 (95% CI: 1.01-1.06)
- BASFI and BASRI not significantly associated with fracture risk
Original publication
Prevalence and relative risk of fractures and osteoporosis in patients with ankylosing spondylitis: a systematic review and meta-analysis. Osteoporos Int. Published 23 January 2026. doi:10.
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