Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis
Authors' conclusion
Our study highlights that BMD at the femoral neck is more effective for evaluating AS patients compared with the BMD at the lumbar spine. Additionally, the risk of osteoporosis and fractures in AS patients is higher in younger patients and those at the early stage of this disease.
Study context
- Population
- Patients with ankylosing spondylitis (AS); studies from Embase, PubMed, Cochrane Library and Web of Science39 studies
- Comparison
- AS patients vs healthy controls
- Outcome
- BMD, osteopenia, osteoporosis and fracture risk at various sites, and risk factors for fractures
Methodological detailssensitivity analysis
- Sensitivity analysis
Pooled result
As reported in the abstract
BMD, AS vs healthy controls
- AS patients had significantly lower bone mineral density (BMD) at the femoral neck, hip, L2, L3 and L4
- AS patients had higher BMD at 1/3 distal radius and ultra distal radius
Further pooled results
Risk factors for fractures in AS
- Risk factors: old age, long disease course, low lumbar spine BMD
- Not risk factors: Erythrocyte sedimentation rate (ESR), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), gender, body mass index (BMI)
Original publication
Bone density and fracture risk factors in ankylosing spondylitis: a meta-analysis. Osteoporos Int. Published 9 October 2023. doi:10.
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