Association of β-adrenergic receptor blockers use with the risk of fracture in adults: a systematic review and meta-analysis
Authors' conclusion
In cohort studies, no association was found between beta-receptor antagonists and fracture risk. However, beta-receptor antagonists have been shown to reduce the risk of fractures in adult users in case-control studies.
Study context
- Population
- Adults; cohort and case-control studies from Embase, Medline, PubMed and Web of Science16 articles
- Participants
- 156,437 vs 432,288
- Comparison
- β-blocker users vs non-users
- Beta-blockers usersn = 156,437
- Non-usersn = 432,288reference
- Outcome
- Fracture risk
Methodological detailsadjusted results, sensitivity analysis, Egger's test
- Adjusted results
- Sensitivity analysis
- Egger's test
Pooled result
As reported in the abstract
Fracture risk (pooled adjusted estimates)
Estimate (95% CI)P value
Beta-receptor antagonists7 cohort studies
HR 0.96(0.88–1.05)
P = 0.41Beta-blockers usersvs Non-users9 case-control studies
OR 0.86(0.77–0.95)
P < 0.0001Further pooled results
Fracture risk by fracture site (subgroup)
- No association between beta-receptor antagonists and fracture risk
Fracture risk stratified by gender (subgroup)
- Beta-receptor antagonists reduce the fracture risk
Original publication
Association of β-adrenergic receptor blockers use with the risk of fracture in adults: a systematic review and meta-analysis. Osteoporos Int. Published 2 April 2025. doi:10.
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