Beverage Consumption, Genetic Predisposition, and Risk of Cardiovascular Disease Among Adults With Type 2 Diabetes
Authors' conclusion
Higher intakes of SSBs, ASBs, and natural juices were each linearly associated with an increased risk of CVD among individuals with T2D, regardless of genetic predisposition. Our findings highlight the importance of selecting healthy beverage options to improve cardiovascular health in patients with T2D.
Study context
- Population
- Adults with T2D, UK Biobank
- Participants
- 7,315 adults
- Exposure
- Highest vs lowest beverage consumption
- Outcome
- Incident CVD
- Follow-up
- Median 6.1 years
Methodological detailsUK Biobank, stratified by cardiovascular disease (CVD) genetic risk
- UK Biobank
- Stratified by CVD genetic risk
Main finding
As reported in the abstract
Incident CVD (878 cases)
Each group vs lowestEstimate (95% CI)
Highest
multivariable-adjusted HR, SSBs 1.54(1.14–2.07)
Highest
multivariable-adjusted HR, ASBs 1.34(1.07–1.69)
Highest
multivariable-adjusted HR, natural juices 1.33(1.01–1.76)
- Higher SSB, ASB and natural juice intakes each linearly associated with higher CVD
- Pnonlinearity > .05
Observational data: associations, not effects.
Further findings
Incident ischemic heart disease (IHD) (517 cases)
- Similar results observed for incident IHD
Interaction with CVD genetic risk score
- No significant interactions between these beverages and the CVD genetic risk score
Substitution of half-unit/day of sugar-sweetened beverages (SSBs) or natural juices with coffee, tea or yogurt, but not artificially sweetened beverages (ASBs)
- Lower risk of CVD and IHD
- 20% to 46%
Original publication
Beverage Consumption, Genetic Predisposition, and Risk of Cardiovascular Disease Among Adults With Type 2 Diabetes. J Clin Endocrinol Metab. Published 27 January 2024. doi:10.
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