Baseline serum PINP is associated with early lumbar spine bone mineral density gains during twice-weekly teriparatide treatment: the OASIS cohort study
Authors' conclusion
Baseline serum PINP represents one of the clinically relevant independent predictors of early LS BMD response to twice-weekly teriparatide.
Study context
- Population
- Osteoporosis patients at high fracture risk (88.0% female, mean age 80.0 years, 83.5% prior osteoporotic fracture, 72.3% treatment-naïve)completed 12 months
- Participants
- 242 patients
- Outcome
- Determinants of early LS BMD improvement (percent LS BMD change; LS BMD increase ≥ 8%)
- Follow-up
- 12 months
Methodological detailsmulticentre, multivariate regression, ROC analysis
- Multicentre
- Multivariate regression
- ROC analysis
Main finding
As reported in the abstract
Baseline PINP as predictor of LS BMD change
- Baseline PINP independently associated with percent lumbar spine (LS) bone mineral density (BMD) change, standardized coefficient (p < 0.001)
- 2.73
- Baseline PINP cutoff for predicting ≥ 8% LS BMD increase (μg/L)
- 53.1
- Sensitivity of PINP cutoff
- 74.4%
- Specificity of PINP cutoff
- 60.5%
- AUC of PINP cutoff
- 0.67
Observational data: associations, not effects.
Further findings
Percent change in LS BMD (mean ± SD) · 12 months
- Percent change in LS BMD, mean ± SD
- 7.0 ± 8.6%
LS BMD increase ≥ 8% · 12 months
- Patients achieving an LS BMD increase ≥ 8%
- 41.3%
Original publication
Baseline serum PINP is associated with early lumbar spine bone mineral density gains during twice-weekly teriparatide treatment: the OASIS cohort study. Osteoporos Int. Published 6 April 2026. doi:10.
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