Influence of bisphosphonate pretreatment on bone mineral density gains and fracture outcomes with teriparatide: A systematic review and meta-analysis
Pooled result · % change in lumbar spine BMD with teriparatideResult — go to the resultMD −2.21 % 95% CI −4.17,−0.25Authors' conclusion
Prior bisphosphonate exposure is associated with modest, site-specific attenuation of lumbar spine BMD gains with teriparatide, without significant effects at non-spinal sites.
Study context
- Population
- Individuals with osteoporosis treated with teriparatide; randomised trials, non-randomised trials, observational studies and post hoc or subgroup analyses15 studies
- Participants
- 8,763 vs 7,071
- Comparison
- Bisphosphonate (BP)-pretreated vs BP-naïve individuals receiving teriparatide
- BP-pretreatedn = 8,763
- BP-naïven = 7,071reference
- Outcome
- % change in lumbar spine bone mineral density (BMD) with teriparatide
Methodological detailsrandom-effects models with Hartung-Knapp adjustment, PRISMA
- Random-effects models with Hartung-Knapp adjustment
- PRISMA
Pooled result
As reported in the abstract
MD
−2.21 %
95% CI −4.17,−0.25
P = 0.027
BP-pretreatedvs BP-naïve
MD −2.21 % (95% CI −4.17,−0.25); P = 0.027
Further pooled results
| Outcome | MD (%) (95% CI) | P value | |
|---|---|---|---|
| % change in hip BMD | −0.88 (−1.98,0.19) | P = 0.108 | |
| % change in femoral neck BMD | −0.52 (−1.36,0.33) | P = 0.230 | |
| −2−101Difference, % (linear scale) |
| Outcome | Estimate | P value | |
|---|---|---|---|
| Incident fracturesBP-pretreatedvs BP-naïvePooled absolute fracture events | OR 1.43 (95% CI 1.09,1.88) | P = 0.009 | |
| Incident fracturesBP-pretreatedvs BP-naïvePooled adjusted HRs; based on only two studies | HR 1.35 (95% CI 0.99,1.83) | P = 0.055 | |
| 0.512Ratio (log scale) |
Original publication
Influence of bisphosphonate pretreatment on bone mineral density gains and fracture outcomes with teriparatide: A systematic review and meta-analysis. Osteoporos Int. Published 15 July 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →