Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case–Control Study in Sweden
Main finding · Prior AITDsResult — go to the resultAdjusted odds ratio 1.65 95% CI 1.54–1.77Authors' conclusion
Individuals with AITDs are at an increased risk of developing MC. That this association was robust across various subgroups may be indicative of shared underlying mechanisms. Our findings highlight the importance of being vigilant of gastrointestinal symptoms in patients with AITDs and that patients with persistent symptoms despite achieving euthyroidism should be evaluated for MC.
Study context
- Population
- Patients with biopsy-confirmed microscopic colitis (collagenous or lymphocytic) diagnosed 2006–2017, Swedish population-based histopathology cohort ESPRESSO, and matched controls
- Participants
- 10,301 vs 48,712
- Comparison
- Prior autoimmune thyroid diseases (AITDs) in microscopic colitis (MC) cases vs matched controls
- MC casesn = 10,301
- Controlsn = 48,712reference
- Outcome
- Association between prior AITDs (Hashimoto thyroiditis, Graves disease) and MC (OR)
Methodological detailssibling comparisons, conditional logistic regression
- Sibling comparisons
- Conditional logistic regression
Main finding
Prior AITDs
Adjusted odds ratio
1.65
95% CI 1.54–1.77
By group
MC casesvs Controls
adjusted OR 1.65 (95% CI 1.54–1.77)
As reported in the abstract
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| AITDs and MC, sibling analysesAttenuated but significant | 1.26 (1.11–1.43) | |
| AITDs and MC diagnosed before age 50 | 2.41 (2.02–2.89) | |
| 0.20.5125Odds ratio (log scale) |
Subgroups: Collagenous colitis (CC) vs lymphocytic colitis (LC); sex
- No difference between CC and LC or between sexes
Original publication
Autoimmune Thyroid Diseases and Microscopic Colitis: A Nationwide Matched Case–Control Study in Sweden. J Clin Endocrinol Metab. Published 5 March 2025. doi:10.
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