Associations of Serum 25(OH)D With Risk of Recurrent Cardiovascular Events in Individuals With Coronary Heart Disease
Main finding · Recurrent CV eventsResult — go to the resultHazard ratio 0.64 95% CI 0.58–0.71Authors' conclusion
In people with established CHD, higher serum 25(OH)D concentrations were nonlinearly associated with a lower risk of recurrent CV events, with a potential threshold around 50 nmol/L. These findings highlight the importance of maintaining adequate vitamin D status in the prevention of recurrent CV events among individuals with CHD.
Study context
- Population
- Individuals with established coronary heart disease, UK Biobank
- Participants
- 22,571 individuals
- Exposure
- Serum 25D categories
- Outcome
- Recurrent CV events (myocardial infarction (MI), heart failure (HF), stroke, CVD mortality) from electronic health records
- Follow-up
- Median 11.2 years
Methodological detailsUK Biobank, multivariable-adjusted Cox proportional-hazard models
- UK Biobank
- Multivariable-adjusted Cox proportional-hazard models
Main finding
Recurrent CV events
Hazard ratio
0.64
95% CI 0.58–0.71
50.0 to 74.9 nmol/Lvs <25.0 nmol/L
HR 0.64 (95% CI 0.58–0.71)
As reported in the abstract
- Nonlinear inverse relationship between serum 25(OH)D and recurrent cardiovascular (CV) events; decreasing risk leveled off at around 50 nmol/L
- P nonlinearity <.01
- Recurrent CV events documented
- 3998
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MI | 0.78 (0.65–0.94) | |
| HF | 0.66 (0.57–0.76) | |
| Stroke | 0.66 (0.52–0.84) | |
| 0.512Hazard ratio (log scale) |
Serum 25(OH)D distribution · baseline
- Median (IQR) serum 25(OH)D
- 44.8 nmol/L (30.3-61.4 nmol/L)
- Participants with 25(OH)D below 50 nmol/L
- 58.6%
Effect modification by vitamin D receptor (VDR) polymorphisms
- Associations not modified by genetic variants in the VDR
Original publication
Associations of Serum 25(OH)D With Risk of Recurrent Cardiovascular Events in Individuals With Coronary Heart Disease. J Clin Endocrinol Metab. Published 6 June 2023. doi:10.
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