Lipids & metabolic liver disease
Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study
Authors' conclusion
Sedentary time worsens lipid indices, but increased LPA had a 5- to 8-fold total cholesterol-lowering effect and was more resistant to the attenuating effect of fat mass than MVPA.
Study context
- Population
- Children from the Avon Longitudinal Study of Parents and Children (ALSPAC) UK birth cohort (58% female; mean age 11.7 years at baseline) with ≥2 accelerometer measures at ages 11, 15 and 24 years and fasting lipids at ages 15, 17 and 24 years
- Participants
- 792 children
- Outcome
- Associations of sedentary time, LPA and MVPA with lipids (HDL-C, LDL-C, TG, total cholesterol), mediation by body composition, and temporal interrelations
Methodological detailsmediation analysis, temporal path analysis, accelerometer-measured
- Mediation analysis
- Temporal path analysis
- Accelerometer-measured
Main finding
As reported in the abstract
Mediation by total fat mass of associations of PA with lipids
- Total fat mass partly mediated inverse association of light physical activity (LPA) with LDL-C
- 13%
- Total fat mass partly mediated inverse association of LPA with TG
- 28%
- Total fat mass partly mediated inverse association of LPA with total cholesterol
- 6%
- Total fat mass mediated inverse association of moderate to vigorous PA (MVPA) with LDL-C
- 37%
- Total fat mass mediated inverse association of MVPA with total cholesterol, attenuating it to nonsignificance (P = .077)
- 48%
Observational data: associations, not effects.
Further findings
Temporal path analysis: MVPA at age 15 years and LDL-C at 24 years · ages 15 to 24 years
- Higher MVPA at 15 years associated with lower LDL-C at 24 years (SE, 0.01, P = .022), but not vice versa
- β = −0.08
Original publication
Associations of Sedentary Time and Physical Activity From Childhood With Lipids: A 13-Year Mediation and Temporal Study. J Clin Endocrinol Metab. Published 14 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →