Lipids & metabolic liver disease
Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population
Authors' conclusion
In a hypertensive population, baseline TyG index was associated with a significantly higher risk of first stroke. In addition, age was a significant effect modifier for this association.
Study context
- Population
- Rural Chinese hypertensive population (China Stroke Primary Prevention Trial (CSPPT)); Triglyceride-glucose (TyG) index = ln [fasting TG (mg/dL) × fasting glucose (mg/dL)/2]
- Participants
- 7,569 participants
- Exposure
- TyG index quartiles
- Outcome
- First stroke
Methodological detailsdata from the China Stroke Primary Prevention Trial (CSPPT), multivariate Cox proportional hazards models
- Data from the China Stroke Primary Prevention Trial (CSPPT)
- Multivariate Cox proportional hazards models
Main finding
As reported in the abstract
- Quartile 2 vs Quartile 1
- HR 1.04
- Quartile 3 vs Quartile 1
- HR 1.43
- Quartile 4 vs Quartile 1
- HR 1.45; P = 0.013 for trend
- Quartiles 3 and 4 (≥ 8.8) vs Quartiles 1 and 2 (< 8.8)
- HR 1.41
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| First stroke, joint effect of TyG index and ageTyG ≥ 8.8 and age ≥60 yearsvs TyG < 8.8 and age < 60 yearsHighest HR among groups | 2.15 (1.50–3.07) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Ischemic stroke
- Similar findings for association of TyG index with ischemic stroke
Original publication
Triglyceride-glucose index is associated with a higher risk of stroke in a hypertensive population. Cardiovasc Diabetol. Published 13 December 2023. doi:10.
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