Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort
Authors' conclusion
Many BMI-associated but few WC-associated DEGs were identified in the blood of women in Norway. The biological functions of BMI-associated DEGs likely reflect systemic impacts of obesity, especially blood reticulocyte-erythrocyte ratio shifts.
Study context
- Population
- Women never diagnosed with cancer in the Norwegian Women and Cancer (NOWAC) postgenome cohort
- Participants
- 1,694 participants
- Exposure
- BMI categories and past weight changes vs blood gene expression
- Outcome
- DEGs by current BMI (BMIQ3)
Methodological detailsGene-wise linear regression models and functional enrichment analyses; three questionnaires: Q1 (baseline), Q2 (follow-up), Q3 (blood collection)
- Gene-wise linear regression models and functional enrichment analyses; three questionnaires: Q1 (baseline), Q2 (follow-up), Q3 (blood collection)
Main finding
As reported in the abstract
Differentially expressed genes (DEGs), obesity vs normal weight
2394
DEGs, obesity vs overweight
769
DEGs, overweight vs normal weight
768
Observational data: associations, not effects.
Further findings
DEGs by weight changes (WCQ3-Q1, mean 7 years; WCQ3-Q2, mean 1 year) in interaction models with BMI categories
- DEGs observed
- up to 169
- Genes associated with weight changes (WCs)
- 1 to 169
- Genes associated with BMI × WC interaction
- 0 to 9
- WC-associated DEGs linked to signal transduction
Original publication
Associations of gene expression in blood with BMI and weight changes among women in the Norwegian Women and Cancer postgenome cohort. Obesity (Silver Spring). Published 7 August 2023. doi:10.
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