Associations of diabesity with all‐cause and cardiovascular disease mortality: Findings from the Mexico City Prospective Study
Main finding · All-cause mortalityResult — go to the resultHazard ratio 2.04 95% CI 1.94–2.15Authors' conclusion
This large prospective study identified that diabetes was the main driver of all-cause and CVD mortality in all the categories studied, with diabesity being the riskiest. Given the high prevalence of both conditions in Mexico, our results reinforce the importance of initiating prevention strategies from an early age.
Study context
- Population
- Mexico City Prospective Study participants (67.2% women); diabetes self-reported, obesity by BMI
- Participants
- 154,128 participants
- Exposure
- Joint diabetes and obesity categories
- Outcome
- All-cause and CVD mortality
- Follow-up
- 18.3 years
Methodological detailsCox proportional hazard models adjusted for confounders
- Cox proportional hazard models adjusted for confounders
Main finding
All-cause mortality
Hazard ratio
2.04
95% CI 1.94–2.15
Diabesityvs Normal
HR 2.04 (95% CI 1.94–2.15)
As reported in the abstract
- Deaths during follow-up
- 27 197 (17.6%)
- Highest all-cause mortality risk, HR (group not named in abstract), maximally adjusted
- 2.37 (95% CI: 2.24-2.51)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD mortalityDiabesityvs NormalHighest CV mortality risk; reference not stated in abstract | 1.80 (1.63–1.99) | |
| CVD mortalityNormal weight and diabetesvs Normal | 1.78 (1.60–1.98) | |
| 0.512Hazard ratio (log scale) |
- Cardiovascular disease (CVD) mortality — Deaths from CV causes
- 28.5%
- CVD mortality: second-highest CV mortality risk; reference not stated in abstract
CVD mortality
- Similar trends of associations as for all-cause mortality
Original publication
Associations of diabesity with all‐cause and cardiovascular disease mortality: Findings from the Mexico City Prospective Study. Diabetes Obes Metab. Published 5 March 2024. doi:10.
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