Bone and radiologic findings in congenital generalized lipodystrophy: a systematic review and report of 60 cases
Authors' conclusion
Individuals with CGL1 and CGL2 present with distinct and heterogeneous bone phenotypes including lytic-appearing lesions primarily affecting long bones, diffuse osteosclerosis, and high bone mineral density.
Study context
- Population
- Patients with congenital generalized lipodystrophy type 1 (AGPAT2) or type 2 (BSCL2)43 articles
- Participants
- 214 vs 60
- Comparison
- Literature vs NIH
- Literaturen = 214
- NIHn = 60
- Outcome
- Bone manifestations and radiological findings associated with CGL1 and CGL2
Methodological detailsretrospective chart review, dual reviewer screening, risk of bias assessed
- Retrospective chart review
- Dual reviewer screening
- Risk of bias assessed
Pooled result
As reported in the abstract
Prevalence of bone findings
Diffuse osteosclerosis, Literature vs NIH
37% vs 39%
Lytic-appearing lesions, Literature vs NIH
64% vs 53%
High BMD, Literature vs NIH
68% vs 43%
Original publication
Bone and radiologic findings in congenital generalized lipodystrophy: a systematic review and report of 60 cases. J Bone Miner Res. Published 13 June 2026. doi:10.
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