The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16
Authors' conclusion
Change in metabolic phenotype is associated with incident 3-point MACE.
Study context
- Population
- Participants of the Panasonic cohort
- Participants
- 117,589 participants
- Exposure
- Transitions of metabolic phenotype vs stable metabolically healthy nonobesity (MHNO)
- Outcome
- 3-point MACE: cardiovascular death, nonfatal coronary artery disease and nonfatal stroke
- Follow-up
- 11 years
Methodological detailsmetabolic phenotype assessed at two points 2 years apart
- Metabolic phenotype assessed at two points 2 years apart
Main finding
As reported in the abstract
3-point MACE
Each group vs stable MHNOHazard ratio (95% CI)
MHO to MHNOrisk decreased to the same level as stable MHNO
1.12(0.84–1.47)
MANO to MHNO
1.66(1.36–2.01)
MAO to MHNO
1.91(1.22–2.81)
- 3-point major adverse cardiac events (MACE) cases during follow-up
- 2748 (2.3%)
Observational data: associations, not effects.
Original publication
The transition of metabolic phenotypes and cardiovascular events: Panasonic cohort study 16. Obesity (Silver Spring). Published 5 March 2024. doi:10.
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