Impact of metabolic phenotype changes on the development of chronic kidney disease: Panasonic cohort study 17
Authors' conclusion
The improvement of metabolic profile might outweigh weight reduction in CKD risk.
Study context
- Population
- Panasonic Holdings Corporation employees aged ≥40 years, health data 2011–2021
- Participants
- 84,729 employees
- Exposure
- Changes in metabolic phenotype over 3 years vs stable phenotype
- Outcome
- CKD development
- Follow-up
- Mean 5.1 years
Methodological detailsCox proportional hazards models adjusted for confounding variables
- Cox proportional hazards models adjusted for confounding variables
Main finding
As reported in the abstract
Hazard ratio (95% CI)
MANO to MHNOvs Stable MANO
0.86(0.77–0.96)
MAO to MHOvs Stable MAO
0.83(0.67–1.02)
- Developed chronic kidney disease (CKD) (all participants)
- 12,172 (14.4%)
Observational data: associations, not effects.
Further findings
Rapid decline in renal function
- The same results were observed as for CKD
Original publication
Impact of metabolic phenotype changes on the development of chronic kidney disease: Panasonic cohort study 17. Obesity (Silver Spring). Published 23 April 2025. doi:10.
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