Associations of adiponectin concentrations from birth until late adolescence with insulin resistance
Authors' conclusion
Overall, starting in mid-childhood, lower adiponectin concentrations were linked with higher insulin resistance in late adolescence, with associations apparent mostly in males.
Study context
- Population
- Children of Project Viva prospective birth cohort, Eastern Massachusetts (1999–2002); 52% female, 59% Non-Hispanic White
- Participants
- 468 children
- Exposure
- Adiponectin z-scores from birth to late adolescence vs HOMA-IR in late adolescence
- Outcome
- Insulin resistance (HOMA-IR)
- Follow-up
- Late adolescence
Methodological detailsmultivariable linear regression
- Multivariable linear regression
Main finding
As reported in the abstract
Association of adiponectin z-score with HOMA-IR in late adolescence
Adiponectin z-score in mid-childhood
−0.16
95% CI −0.33, 0.01
Adiponectin z-score in early adolescence
−0.19
95% CI −0.37, −0.01
Adiponectin z-score in late adolescence
−0.40
95% CI −0.57, −0.23
Observational data: associations, not effects.
Further findings
Sex-stratified associations
- Associations observed in males; estimates more modest in females
Original publication
Associations of adiponectin concentrations from birth until late adolescence with insulin resistance. Pediatr Obes. Published 23 April 2025. doi:10.
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