Baseline Body Fat Percentage Is Associated to Weight and Fat Mass Gain From High-Fat Overfeeding Over 8 Weeks
Authors' conclusion
Body fat percentage at baseline was inversely associated with overfeeding-induced weight and fat gain resistance. The underlying compensatory response appears unrelated to changes in energy expenditure.
Study context
- Population
- Men aged 26 ± 5 years, body mass index (BMI) 25.5 ± 2.4 kg/m², body fat (DXA) 19.3 ± 5.1%, overfed 40% more energy than needed at weight maintenance for 8 weeks
- Participants
- 34 men
- Outcome
- Relationship of overfeeding-induced weight and fat mass gains with baseline BMI and body fat percentage
- Follow-up
- 8 weeks
Methodological detailssingle-group overfeeding, 8 weeks
- Single-group overfeeding
- 8 weeks
Main finding
As reported in the abstract
Association of baseline BMI and body fat percentage with weight and fat mass gains
Body weight increase
7.2 ± 2.1 kg
Fat mass increase
4.0 ± 1.4 kg
Baseline body fat % vs weight gain
r = 0.57
Baseline body fat % vs fat mass gain
r = 0.59
Further findings
Energy cost of weight and fat mass gains
- Body fat % vs energy cost of weight gain
- r = −0.38
- Body fat % vs energy cost of fat mass gain
- r = −0.40
- Adaptive thermogenesis unrelated to energy cost of weight and fat mass gains
Adipose tissue transcriptomics
- High energy cost of weight gain associated with upregulation of inflammation-related pathways
Original publication
Baseline Body Fat Percentage Is Associated to Weight and Fat Mass Gain From High-Fat Overfeeding Over 8 Weeks. J Clin Endocrinol Metab. Published 21 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →