Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial
Authors' conclusion
Our findings suggest pasteurized A. muciniphila MucT as a strategy for weight loss maintenance.
Study context
- Population
- Adults with overweight/obesity after an 8-week low-energy diet for ≥8% weight loss, followed by a 24-week healthy ad libitum diet
- Participants
- 90 adults
- Comparison
- Pasteurized A. muciniphila MucT vs placebo for weight loss maintenance
- Primary endpoint
- Change in body weight during the maintenance period
- Follow-up
- End of weight maintenance period
Methodological detailsplacebo-controlled
- Placebo-controlled
Primary result
As reported in the abstract
Body weight regain
P = 0.012
Further findings
| Outcome | Difference (kg) | P value |
|---|---|---|
| Net weight loss from baseline to end of maintenanceGreater net weight loss with MucT; ± 0.7 kg | 3.1 | P = 0.009 |
Akkermansia spp. abundance
- Initial Akkermansia spp. abundance was associated with cardiometabolic response to MucT
Safety
- No serious adverse events related to the treatment
Original publication
Pasteurized Akkermansia muciniphila MucT for weight loss maintenance in people with overweight and obesity: a controlled randomized trial. Nat Med. Published 13 May 2026. doi:10.
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