Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank
Authors' conclusion
Sufficient dietary Mg intake was significantly associated with lower risks of ASCVD events and mortality in individuals with type 2 diabetes but not in those without type 2 diabetes. Our findings provide insight into the importance of dietary Mg intake for reducing modifiable cardiovascular burden in individuals with type 2 diabetes, which may inform future personalized dietary guidelines.
Study context
- Population
- UK Biobank participants with and without T2D4,603 with T2D
- Participants
- 149,929 participants
- Exposure
- Sufficient dietary magnesium (Mg) intake (≥ recommended daily intake) vs insufficient, in individuals with and without T2D
- Outcome
- Incident ASCVD events and mortality (ASCVD and all-cause)
- Follow-up
- Median 12.0 and 12.1 years
Methodological detailsUK Biobank, Cox proportional hazard models, interaction on multiplicative and additive scales
- UK Biobank
- Cox proportional hazard models
- Interaction on multiplicative and additive scales
Main finding
As reported in the abstract
ASCVD incidence, ASCVD mortality and all-cause mortality by T2D status
Sufficient Mg intake vs Insufficient Mg intakeHazard ratio (95 % CI)
ASCVD incidence, T2D
0.63(0.49–0.82)
ASCVD mortality, T2D
0.45(0.24–0.87)
All-cause mortality, T2D
0.71(0.52–0.97)
ASCVD incidence, without T2D
1.01(0.94–1.09)
ASCVD mortality, without T2D
1.25(0.93–1.66)
All-cause mortality, without T2D
0.97(0.88–1.07)
- Incident atherosclerotic cardiovascular disease (ASCVD) events
- 7811
- Deaths (including 599 ASCVD deaths)
- 5000
Observational data: associations, not effects.
Original publication
Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank. Diabetes Metab. Published 29 June 2024. doi:10.
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