Associations of circulating total p-cresylsulfate and indoxyl sulfate concentrations with central obesity in patients with stable coronary artery disease: sex-specific insights
Authors' conclusion
Circulating total PCS and IS contribute to central obesity in male patients with stable CAD, partially mediated by hs-CRP.
Study context
- Population
- Consecutive patients with stable coronary artery disease, single center
- Participants
- 373 patients
- Exposure
- High vs low total p-cresylsulfate (PCS) and indoxyl sulfate (IS) levels
- Outcome
- Central obesity (ABSI and conicity index) in relation to total PCS and IS levels
Methodological detailssingle-centre, consecutive patients, structural equation modeling
- Single-centre
- Consecutive patients
- Structural equation modeling
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
High PCSvs Low PCSelevated CI
3.18(1.54–6.75)
P = 0.002High PCSvs Low PCSelevated ABSI
3.28(1.54–7.24)
P = 0.002High ISvs Low ISelevated CI
2.30(1.15–4.66)
P = 0.018High ISvs Low ISelevated ABSI
2.22(1.07–4.72)
P = 0.033Observational data: associations, not effects.
Further findings
Correlations with waist-to-hip ratio (WHR), CI and a body shape index (ABSI) in male patients
- Total PCS vs WHR
- r = 0.174, p = 0.005
- IS vs WHR
- r = 0.144, p = 0.021
- Total PCS vs CI
- r = 0.273, p < 0.0001
- IS vs CI
- r = 0.260, p < 0.0001
- Total PCS vs ABSI
- r = 0.297, p < 0.0001
- IS vs ABSI
- r = 0.285, p < 0.0001
- No significant correlations in female patients
Structural equation modeling (SEM): indirect effect on central adiposity (WHR) through high sensitivity C-reactive protein (hs-CRP)
- Total PCS and IS directly impacted central obesity indices; indirect effect via hs-CRP
- β = 0.252, p < 0.001
Original publication
Associations of circulating total p-cresylsulfate and indoxyl sulfate concentrations with central obesity in patients with stable coronary artery disease: sex-specific insights. Int J Obes (Lond). Published 5 September 2024. doi:10.
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