Intra-pancreatic fat is associated with high circulating glucagon and GLP-1 concentrations following whey protein ingestion in overweight women with impaired fasting glucose: A randomised controlled trial
Authors' conclusion
In our cohort, there was no evidence that IPFD impaired protein-induced insulin secretion. Conversely, IPFD may be associated with increased protein-induced glucagon secretion, a novel observation which warrants further investigation into its relevance in the pathogenesis of dysglycaemia and type-2 diabetes.
Study context
- Population
- Overweight women with impaired fasting glucose; beverages of 0 g (water control), 12.5 g (low-dose) and 50.0 g (high-dose) whey protein after overnight fast
- Participants
- 20 women
- Comparison
- High vs low intra-pancreatic fat deposition after whey protein ingestion
- Primary endpoint
- Postprandial iAUC, iCmax and Tmax of glucose, insulin, C-peptide, glucagon, gastric-inhibitory polypeptide (GIP), GLP-1 and amylin compared between IPFD groups (repeated measures linear mixed models, also age-adjusted)
- Follow-up
- Over 4 h
Methodological detailscrossover (3 beverage treatments in randomised order)
- Crossover (3 beverage treatments in randomised order)
Primary result
As reported in the abstract
Postprandial glucose, insulin, glucagon and GLP-1
- Incremental area-under-the-curve (iAUC) and iCmax glucose and insulin similar between intra-pancreatic fat deposition (IPFD) groups
- High IPFD and ageing contributed to higher postprandial glucagon and GLP-1
- High IPFD vs Low IPFD: P = 0.012; pcov = 0.004
- High IPFD vs Low IPFD: P = 0.069; pcov = 0.021
- High IPFD vs Low IPFD: P = 0.006; pcov = 0.064
- High IPFD vs Low IPFD: P = 0.011; pcov = 0.122
- Pcov = controlled for age
Original publication
Intra-pancreatic fat is associated with high circulating glucagon and GLP-1 concentrations following whey protein ingestion in overweight women with impaired fasting glucose: A randomised controlled trial. Diabetes Res Clin Pract. Published 27 December 2023. doi:10.
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