Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants
Authors' conclusion
These findings indicate that lower protein synthesis observed in muscle of humans with obesity may result from diminished muscle IGF1 gene expression.
Study context
- Population
- Humans with and without obesity; skeletal muscle studied after an overnight fast
- Participants
- 9 vs 9
- Exposure
- Obesity vs without obesity
- Obesity (OB)n = 9
- Without obesity (W-OB)n = 9reference
- Outcome
- Muscle IGF-1 protein and mRNA splice variant expression in relation to MMP-FSR
Main finding
As reported in the abstract
Muscle IGF-1 signalling and protein synthesis · after overnight fast
| Group | Value | BMI (kg/m²), mean [SD] |
|---|---|---|
| OB | mean 0.06 (SD 0.02%/h) %/h | 35 [3] |
| W-OB | mean 0.08 (SD 0.02%/h) %/h | 24 [3] |
Value
OBmean 0.06 (SD 0.02%/h) %/h
W-OBmean 0.08 (SD 0.02%/h) %/h
BMI (kg/m²), mean [SD]
OB35 [3]
W-OB24 [3]
- OB vs W-OB: P < 0.05 — mixed-muscle protein fractional synthesis rate (MMP-FSR) and BMI lower/higher: MMP-FSR lower with OB
- OB vs W-OB: P = 0.04 — IGF-1 protein lower with OB
- OB vs W-OB: P < 0.01 — IGF-1 receptor protein lower with OB
- OB vs W-OB: P < 0.05 — IGF1 Eb and Ec mRNA lower with OB
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Mitochondrial protein FSR · after overnight fastLower with OB | P = 0.03 |
Original publication
Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants. Obesity (Silver Spring). Published 16 October 2023. doi:10.
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