Life’s Essential 8 and Mortality in US Adults With Obesity: A Cohort Study
Authors' conclusion
Higher LE8 scores are significantly associated with lower rates of all-cause, CVD, and non-CVD mortality among obese individuals. These findings support the LE8 scoring system as an effective predictor of health status and mortality risk.
Study context
- Population
- US adults with obesity (BMI ≥30 kg/m²), NHANES 2005–2018
- Participants
- 9,143 adults
- Exposure
- Moderate CVH and High CVH vs Low CVH
- Low CVHn = 2,264reference
- Moderate CVHn = 6,541
- High CVHn = 338
- Outcome
- All-cause mortality
- Follow-up
- Median 7.3 years
Methodological detailsNHANES 2005–2018, multivariable Cox regression
- NHANES 2005–2018
- Multivariable Cox regression
Main finding
As reported in the abstract
Each group vs low CVHEstimate (95% CI)
Moderate CVH
aHR 0.63(0.55–0.72)
High CVH
HR 0.25(0.10–0.60)
- All-cause deaths
- 867 (9.5%)
- Reduction in all-cause mortality per 10-point increase in LE8 score (P < .001)
- 20%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| CVD mortalityModerate CVHvs Low CVH | 0.61 (0.47–0.78) | |
| CVD mortalityHigh CVHvs Low CVH | 0.19 (0.03–1.38) | |
| Non-CVD mortalityModerate CVHvs Low CVH | 0.64 (0.54–0.75) | |
| Non-CVD mortalityHigh CVHvs Low CVH | 0.27 (0.10–0.72) | |
| 0.050.21520Hazard ratio (log scale) |
- Cardiovascular disease (CVD) mortality — CVD deaths
- 246 (2.7%)
- CVD mortality — Reduction in CVD mortality per 10-point increase in LE8 score (P < .001)
- 21%
- Non-CVD mortality — Non-CVD deaths
- 621 (6.8%)
- Non-CVD mortality — Reduction in non-CVD mortality per 10-point increase in LE8 score (P < .001)
- 20%
Original publication
Life’s Essential 8 and Mortality in US Adults With Obesity: A Cohort Study. Endocr Pract. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →