Impact of aging on long-term cardiac outcomes of true-lumen recanalized chronic total occlusions in patients with overweight/obesity
Authors' conclusion
For those with true-lumen recanalized CTO, the higher risk of TVMI after successful recanalization was rather evident in patients <65 years of age and without overweight/obesity, suggesting that aging might attenuate prognostic significance of "obesity paradox" for CTO interventions.
Study context
- Population
- Patients with chronic total occlusion (CTO) interventions; 64.4 ± 11.3 years, 403 male422 successful true-lumen recanalization
- Participants
- 458 patients
- Exposure
- Overweight/obesity vs non-obesity
- Overweight/obesityn = 311
- Non-obesityn = 147reference
- Outcome
- TLF: cardiac death, target vessel MI (TVMI), target lesion revascularization (TLR)
- Follow-up
- Median 40.0 (17.9-61.4) months
Main finding
As reported in the abstract
Event rates (whole cohort) · median follow-up
Cardiac death
1.9%
Target vessel myocardial infarction (TVMI)
1.9%
Target lesion revascularization (TLR)
9.2%
TLF
10.7%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| TVMI-free survivalBorderline better with Overweight/obesity | P = 0.067 by log-rank test |
| TVMI-free survival, age <65 yearsSignificantly better with Overweight/obesity | P = 0.013 compared to non-obesity group by log-rank test |
TVMI risk, non-obesity <65 years (multivariate Cox)
- HR among those <65 years
- 11.0 (95% CI 1.1-106.0)
- HR among whole patients with successful CTO recanalization
- 6.9 (95% CI 1.4-35.1)
Safety
Stent thrombosis · median follow-up
- Stent thrombosis rate
- 0.5%
Original publication
Impact of aging on long-term cardiac outcomes of true-lumen recanalized chronic total occlusions in patients with overweight/obesity. Int J Obes (Lond). Published 4 September 2024. doi:10.
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