Association of triglyceride-glucose index trajectories with the risk of worsening heart failure in elderly patients with chronic heart failure and type 2 diabetes: a competing risk analysis
Authors' conclusion
During follow-up, a higher baseline level of TyG index and a high decreasing trajectory were independently associated with long-term worsening heart failure and an increased risk of overall mortality.
Study context
- Population
- Patients aged ≥60 years with chronic HF and T2D with ≥3 medical exams
- Participants
- 466 patients
- Exposure
- TyG index quartiles and trajectories
- Outcome
- Worsening HF and overall mortality
Methodological detailslongitudinal, competing risk analysis, linear mixed models, mixed-effects Cox regression
- Longitudinal
- Competing risk analysis
- Linear mixed models
- Mixed-effects Cox regression
Main finding
As reported in the abstract
Worsening HF
Adjusted hazard ratio (CI)
Top quartilevs First quartile10-year follow-up
2.40(1.35–3.28)
Top quartilevs First quartileoverall follow-up
2.09(1.22–3.58)
High decreasing trajectoryvs Low decreasing trajectory5-year follow-up
1.37(1.10–1.71)
High decreasing trajectoryvs Low decreasing trajectory10-year follow-up
1.78(1.10–2.88)
High decreasing trajectoryvs Low decreasing trajectoryoverall follow-up
1.67(1.04–2.68)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (CI) | |
|---|---|---|
| Overall mortality, TyG index quartilesTop quartilevs First quartile10-year follow-up | 1.99 (1.56–3.14) | |
| Overall mortality, TyG index quartilesTop quartilevs First quartileOverall follow-up duration | 1.87 (1.22–2.88) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
Overall mortality, TyG index trajectory analysis
- aHR for overall mortality, 10-year follow-up
- 2.16 (1.39-3.35)
- aHR for overall mortality, overall follow-up duration
- 2.23 (1.46-3.40)
Original publication
Association of triglyceride-glucose index trajectories with the risk of worsening heart failure in elderly patients with chronic heart failure and type 2 diabetes: a competing risk analysis. Cardiovasc Diabetol. Published 21 March 2025. doi:10.
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