Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database
Main finding · All-cause mortalityResult — go to the resultHazard ratio 0.74 95% CI 0.68–0.93Authors' conclusion
Lower TyG-BMI independently predicted increased short-, intermediate-, and long-term mortality in elderly patients with severe HF and T2DM. This composite index-integrating metabolic (TyG) and nutritional (BMI) dimensions-provides practical risk stratification, particularly within identified threshold ranges.
Study context
- Population
- Elderly patients (aged >65 years) with severe heart failure (HF) and T2D; TyG-BMI at ICU admission; mean age 72.79 ± 7.84 years, 41.5% male
- Participants
- 4,523 patients
- Exposure
- TyG-BMI quartiles
- Outcome
- All-cause mortality
- Follow-up
- 60, 90, 180 and 365 days
Methodological detailsMIMIC-IV database
- MIMIC-IV database
Main finding
As reported in the abstract
90 and 365 days
Hazard ratio
0.74
95% CI 0.68–0.93
Q4vs Q1
HR 0.74 (95% CI 0.68–0.93)
- 90-day mortality, Q1 vs Q4
- 58.70% vs. 48.45%; p = 0.008
- 365-day mortality, Q1 vs Q4
- 80.54% vs. 73.91%; p < 0.001
- 60-day mortality, Q1 vs Q4 (similar trend)
- 58.79% vs. 39.34%; p = 0.059
Observational data: associations, not effects.
Further findings
Subgroups
- Pronounced risk reduction in HFrEF (LVEF ≤40%)
- all-timepoint HR >1, p<0.05
- 365-day aHR, no prior MI vs prior MI
- 0.69 vs. 0.81
- Consistent inverse TyG-BMI–mortality association across all strata (age, cardiac function, comorbidities)
Restricted cubic splines (RCS) nonlinear thresholds of TyG-BMI
- Threshold for 60-day mortality
- 148.73
- Threshold for 365-day mortality
- 163.38
- Below threshold each unit increase conferred greater protective effects
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association between triglyceride-glucose-body mass index and adverse prognosis in elderly patients with severe heart failure and type 2 diabetes: a retrospective study based on the MIMIC-IV database. Cardiovasc Diabetol. Published 24 July 2025. doi:10.
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