Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look AHEAD trial
Authors' conclusion
The small additional benefit of ILI in people eligible for remission, compared with ineligible people, may not be enough to justify restricting resources for ILI to such eligible people.
Study context
- Population
- Overweight and obese people with T2D aged 20–65 years, BMI 27–45 kg/m², Look AHEAD trial; 60% women, median age 58 years; 54% eligible for remission
- Participants
- 3,105 participants
- Comparison
- Intensive lifestyle intervention (ILI) effect in remission-eligible vs ineligible people
Methodological detailsstratified by remission eligibility at baseline
- Stratified by remission eligibility at baseline
Primary result
As reported in the abstract
Effect of ILI on CVD, CKD and mortality by remission eligibility · median follow-up 9 years (IQR 8-10 years)
- Remission eligibility status did not modify the effect of ILI on CVD, chronic kidney disease (CKD), or mortality
Further findings
| Outcome | Eligible | Ineligible | Estimate |
|---|---|---|---|
| Weight change with ILIGreater weight loss with Eligible | −5.53 (95% CI −6.02–-5.03) kg | −3.17 (95% CI −3.86–-2.49) kg | difference 2.4 kg |
| HbA1c change with ILIGreater HbA1c reduction with Eligible | −0.28% (95% CI −0.33–-0.23) | −0.17% (95% CI −0.23–-0.11) | difference 0.1% |
Original publication
Impact of eligibility for diabetes remission on response to intensive lifestyle intervention in overweight and obese people with type 2 diabetes: The Look AHEAD trial. Diabetes Obes Metab. Published 24 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →