Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study
Authors' conclusion
Lower serum sclerostin levels were associated with elevated risks for increased arterial stiffness in Japanese community-dwelling women.
Study context
- Population
- Japanese community-dwelling women aged ≥50 years from the JPOS study with baseline brachial-ankle pulse wave velocity (baPWV) <1800 cm/s (2011–2012)analysed at follow-up
- Participants
- 556 women
- Exposure
- Low and medium vs high tertile of baseline serum sclerostin
- Outcome
- Increased arterial stiffness (baPWV ≥1800 cm/s)
- Follow-up
- 4- to 5-year follow-up
Methodological detailslongitudinal, community-dwelling
- Longitudinal
- Community-dwelling
Main finding
As reported in the abstract
Increased arterial stiffness (baPWV ≥ 1800 cm/s) · mean follow-up 4.0 years
Odds ratio
1.58
P = 0.205
Medium tertile · adjusted for age and baseline baPWV
Odds ratio
2.16
P = 0.027
Low tertile · adjusted for age and baseline baPWV
Odds ratio
2.50
P = 0.014
Low tertile · further adjusted for BMI, hypertension, hyperlipidemia, DM, eGFR, whole-body bone mineral content
- Increased arterial stiffness events
- 94 women
- Trend across tertiles
- trend test P = .013
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Lower Serum Sclerostin Levels With Elevated Risk for Increased Arterial Stiffness: The JPOS Cohort Study. J Clin Endocrinol Metab. Published 12 November 2024. doi:10.
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