Impaired Bone Tissue Quality Associated With Inflammation in HIV-immunological Nonresponders: A Cross-sectional Analysis
Authors' conclusion
INRs' condition is significantly associated with higher inflammatory levels, which may contribute to a deleterious effect on bone quality as measured by in vivo microindentation. Further studies are needed to confirm these results and to focus on non-AIDS comorbidities in this subgroup of PWH.
Study context
- Population
- People with HIV on Antiretroviral Treatment (ART), Hospital del Mar, Barcelona, January 2019 to June 2023matched 1:2
- Participants
- 159 people
- Exposure
- HIV immunological nonresponders vs immune responders
- Immunological nonresponders (INRs)n = 53
- Immune response (IRs)n = 106reference
- Outcome
- Bone quality by in vivo microindentation (bone material strength index)
Methodological detailssingle-centre, matched 1:2 (INRs:IRs) on age, sex, BMI and ART
- Single-centre
- Matched 1:2 (INRs:IRs) on age, sex, BMI and ART
Main finding
As reported in the abstract
Bone material strength index
INRs
79
median · IQR 76–87
IRs
86
median · IQR 82–89
P < 0.001
Observational data: associations, not effects.
Further findings
Bone mineral density (BMD)
- Similar BMD in INRs and IRs
Inflammation and vitamin D
- INRs had increased high-sensitive C-reactive protein with lower 25-(OH)-vitamin D3
- Significant negative correlation between inflammation and bone quality, especially in INRs
Predictors of bone quality
- INR status a major predictor of decreased bone quality regardless of conventional risk factors (multivariable linear regression)
Original publication
Impaired Bone Tissue Quality Associated With Inflammation in HIV-immunological Nonresponders: A Cross-sectional Analysis. J Clin Endocrinol Metab. Published 11 November 2024. doi:10.
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