Association of Elevated Lipoprotein(a) and Diabetes Mellitus With Survival Outcomes in Patients With Coronary Artery Disease: Findings From the CIN ‐ II and RED ‐ CARPET Cohorts
Authors' conclusion
In patients with CAD, elevated Lp(a) and DM act synergistically to increase the risk of cardiovascular and all-cause mortality, suggesting that both risks should be considered to integrate management.
Study context
- Population
- Coronary artery disease (CAD) patients from CIN-II and RED-CARPET cohorts (62.6 ± 10.7 years, 27.7% female)
- Participants
- 65,547 patients
- Exposure
- Lp ≥30 mg/dL and/or diabetes mellitus (DM) vs Lp <30 mg/dL without DM
- Outcome
- Cardiovascular and all-cause mortality
- Follow-up
- Median 5.5 years
Methodological detailstwo cohorts (CIN-II and RED-CARPET), multivariable Cox regression
- Two cohorts (CIN-II and RED-CARPET)
- Multivariable Cox regression
Main finding
As reported in the abstract
Cardiovascular mortality
Each group vs Lp(a) <30 mg/dL without DMAdjusted hazard ratio (95% CI)P value
Lp(a) ≥30 mg/dL without DM
1.26(1.16–1.36)
P < 0.001Lp(a) <30 mg/dL with DM
1.51(1.40–1.62)
P < 0.001Lp(a) ≥30 mg/dL with DM
2.00(1.83–2.18)
P < 0.001- Lp(a) ≥30 mg/dL independently associated with CV mortality, aHR
- 1.28 (95% CI 1.20-1.35; p < 0.001)
- DM independently associated with CV mortality, aHR
- 1.53 (95% CI 1.44-1.62; p < 0.001)
- Significant additive interaction between elevated Lp(a) and DM on CV mortality; share of excess risk attributed
- 12%
Observational data: associations, not effects.
Further findings
All-cause mortality · median follow-up 5.5 years
- Deaths from all causes (overall)
- 10 686 (16.3%)
- Similar associations observed in all-cause mortality
Original publication
Association of Elevated Lipoprotein(a) and Diabetes Mellitus With Survival Outcomes in Patients With Coronary Artery Disease: Findings From the CIN ‐ II and RED ‐ CARPET Cohorts. Diabetes Obes Metab. Published 27 February 2026. doi:10.
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