The impact of remnant lipoprotein cholesterol on the prognosis of patients undergoing percutaneous coronary intervention (PCI) under different glycemic states: a prospective cohort study
Main finding · MACE in non-diabetic patientsResult — go to the resultHazard ratio 1.309 95 % CI 1.083–1.581Authors' conclusion
Elevated RLP-C levels are associated with a greater risk of adverse cardiovascular events in non-diabetic CAD patients post-PCI, suggesting RLP-C as a potential prognostic marker. Further studies are warranted to explore these associations and their implications for treatment strategies.
Study context
- Population
- Coronary artery disease (CAD) patients undergoing PCI, January–December 2013, a cardiovascular hospital in China; stratified by presence or absence of diabetes
- Participants
- 9,440 patients
- Exposure
- High vs low remnant lipoprotein cholesterol (RLP-C), in diabetic and non-diabetic patients
- High RLP-Cn = 4,834
- Outcome
- MACE: all-cause mortality, non-fatal myocardial infarction (MI), stroke and unplanned revascularization
Methodological detailssingle-centre
- Single-centre
Main finding
MACE in non-diabetic patients
Hazard ratio
1.309
95 % CI 1.083–1.581
P < 0.05
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95 % CI) | P value | |
|---|---|---|---|
| Unplanned revascularization, non-diabetic patients | 1.297 (1.066–1.578) | P < 0.05 | |
| 0.512Hazard ratio (log scale) |
Major adverse cardiovascular events (MACE) adjusted for LDL-C, non-diabetic patients
- RLP-C associated with increased risk of MACE after adjusting for LDL-C (HR, 95 % CI, P)
- HR 1.291, 95 % CI 1.066-1.564, P < 0.05
MACE adjusted for non-HDL-C, non-diabetic patients
- RLP-C associated with increased risk of MACE after adjusting for non-HDL-C (HR, 95 % CI, P)
- HR 1.287, 95 % CI 1.052-1.574, P < 0.05
MACE and unplanned revascularization, all patients (Kaplan-Meier)
- Significantly higher MACE rates and unplanned revascularization with high vs low RLP-C
Diabetic patients
- No significant associations observed among diabetic patients
Original publication
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