Management and outcomes of people presenting with new diabetes-related foot infections: a prospective observational study from Australia and New Zealand
Authors' conclusion
Healing at 6 months following DFI does not appear to be associated with infection severity or antibiotic management. To plan clinical trials of antibiotic therapy for DFI, further work is required to define target subgroups and meaningful trial endpoints.
Study context
- Population
- Patients with diabetes, a foot ulcer and a newly diagnosed DFI, 20 Australian and New Zealand centres, 2018–2020; mean age 61 years, 77% male
- Participants
- 234 patients20 centers
- Exposure
- Mild DFI vs moderate/severe DFI without osteomyelitis vs moderate/severe DFI with osteomyelitis
- Outcome
- Healing of the index ulcer or amputation site
- Follow-up
- 6 months
Methodological detailsmulticentre, Multivariable logistic regression adjusted for potential confounders
- Multicentre
- Multivariable logistic regression adjusted for potential confounders
Main finding
As reported in the abstract
Healing
Observational data: associations, not effects.
Further findings
Total antibiotic management duration
Infection severity distribution
Pathogens identified
- Methicillin-resistant Staphylococcus aureus
- 7% (16/214)
- Pseudomonas aeruginosa
- 3% (7/214)
Original publication
Management and outcomes of people presenting with new diabetes-related foot infections: a prospective observational study from Australia and New Zealand. BMJ Open Diabetes Res Care. Published 26 February 2026. doi:10.
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