The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study
Authors' conclusion
A higher TyG index was linked to an increased likelihood of CVD in the U.S. population aged ≤ 65 years with prediabetes and diabetes. Besides, TyG index assessment will contribute to more convenient and effective screening of high-risk individuals in patients with MetS. Future studies should explore whether interventions targeting the TyG index may improve clinical outcomes in these patients.
Study context
- Population
- US participants aged ≤65 years with diabetes or prediabetes, National Health and Nutrition Examination Survey (NHANES) 2003–2018
- Participants
- 4,340 participants
- Exposure
- Triglyceride-glucose (TyG) index quartiles
- Outcome
- CVD risk in relation to baseline TyG index
Methodological detailspopulation-based, NHANES 2003-2018, multivariate regression, restricted cubic splines, subgroup analysis and interaction tests
- Population-based
- NHANES 2003-2018
- Multivariate regression
- Restricted cubic splines
- Subgroup analysis and interaction tests
Main finding
As reported in the abstract
CVD prevalence by TyG quartile
- Overall average prevalence of cardiovascular disease (CVD)
- 10.38%
- Mean TyG index
- 9.02 ± 0.02
Observational data: associations, not effects.
Further findings
CVD and CHF in individuals with diabetes (U-shaped relationship)
- U-shaped relationship TyG index and CVD risk
- P nonlinear = 0.02583
- U-shaped relationship TyG index and CHF risk
- P nonlinear = 0.0208
Subgroup analysis and interaction
- No significant difference among different stratifications
Comorbid MetS
- Positive association between TyG index and comorbid MetS
Original publication
The association between the triglyceride–glucose index and the risk of cardiovascular disease in US population aged ≤ 65 years with prediabetes or diabetes: a population-based study. Cardiovasc Diabetol. Published 13 May 2024. doi:10.
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