Effect of abdominal tissue thickness on trabecular bone score and fracture risk in adults with diabetes: the Manitoba BMD registry
Authors' conclusion
In conclusion, TBS predicts fractures independent of other clinical risk factors in both women and men, with and without diabetes. Excess abdominal tissue thickness in men and individuals with type 2 diabetes may artifactually lower TBS using the current algorithm, which reverses after accounting for tissue thickness.
Study context
- Population
- Individuals aged 40 years and older from a large DXA registry (Manitoba BMD registry)
- Exposure
- Trabecular bone score (TBS) with vs without adjustment for abdominal tissue thickness, by sex and diabetes status
- Outcome
- TBS, not adjusted for abdominal tissue thickness
Methodological detailsstratified by sex and diabetes status
- Stratified by sex and diabetes status
Main finding
As reported in the abstract
Mean difference
−0.074
P < 0.001
Men without diabetes vs Women without diabetes
Mean difference
−0.037
P < 0.001
Women with diabetes vs Women without diabetes
Mean difference
−0.007
P = 0.042
Men with diabetes vs Men without diabetes
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference | P value |
|---|---|---|
| TBS adjusted for abdominal tissue thicknessMen without diabetes vs Women without diabetes | +0.053 | P < 0.001 |
| TBS adjusted for abdominal tissue thicknessWomen with diabetes vs Women without diabetes | +0.008 | P < 0.001 |
| TBS adjusted for abdominal tissue thicknessMen with diabetes vs Men without diabetes | +0.014 | P < 0.001 |
Incident major osteoporotic fractures · mean 8.7 years
- Incident major osteoporotic fractures
- 7048 (9.6%)
- Adjusted for covariates except tissue thickness, TBS predicted fracture in all subgroups with no significant diabetes interaction
- Further adjusted for tissue thickness, HR per SD lower TBS remained significant and increased slightly
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →