Association between triglyceride-glucose index combined with a body shape index and atherosclerotic cardiovascular disease risk varies by glycemic status: insights from the UK Biobank
Authors' conclusion
In the normoglycemia subgroup, the association between the TyG-ABSI and ASCVD was nonlinear. Moreover, the TyG-ABSI was linearly associated with an increased risk of ASCVD in the diabetes subgroup but not in the dysglycemia subgroup. The predictive value of the TyG-ABSI across different glycemic statuses provides new evidence for medical practice. Furthermore, the TyG-ABSI may serve as a useful tool for identifying high-risk individuals within the seemingly low-risk normoglycemic population and for further risk identification among diabetic patients.
Study context
- Population
- UK Biobank participants with normoglycemia, dysglycemia (prediabetes) or diabetes29,680 atherosclerotic cardiovascular disease (ASCVD) events
- Exposure
- Higher vs lower TyG-ABSI, by glycemic status
- Outcome
- Incidence of all-cause ASCVD
- Follow-up
- Average 14.8 years
Methodological detailsUK Biobank, Cox regression, restricted cubic spline, time-dependent ROC, mediation analysis
- UK Biobank
- Cox regression
- Restricted cubic spline
- Time-dependent ROC
- Mediation analysis
Main finding
As reported in the abstract
| Group | HR | P for nonlinear |
|---|---|---|
| Normoglycemia | 1.07 (95% CI 1.05-1.09) | < 0.001 |
| Diabetes | 1.10 (95% CI 1.06-1.14) | = 0.96 |
HR
P for nonlinear
Observational data: associations, not effects.
Further findings
| Outcome | Normoglycemia |
|---|---|
| Predictive performance of TyG-ABSI vs TyG index and other TyG-derived metrics · 10 years | |
| AUC | 0.634 |
Predictive performance of TyG-ABSI vs triglyceride-glucose (TyG) index and other TyG-derived metrics · 10 years
- TyG-ABSI showed superior predictive performance
Mediation of TyG-ABSI–ASCVD association
- White blood cell (WBC) count mediation proportions
- 3.74-9.73%
- C-reactive protein (CRP) mediation proportions
- 9.96-26.89%
Subgroup and sensitivity analyses
- Confirmed robustness of findings
Original publication
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