Association between the fatty acid amide hydrolase (FAAH) C385A variant (rs324420) and obesity-related traits: a systematic review
Authors' conclusion
We show some evidence of associations between the presence of the variant allele and higher body mass index, waist circumference, fat mass, and waist-to-hip ratio levels and alterations in glucose and lipid homeostasis.
Study context
- Population
- Individuals in studies of the FAAH rs324,420 variant and obesity-related traits; PubMed, Web of Science and Scopus
- Participants
- 28,183 individuals28 studies
- Comparison
- FAAH rs324420 variant allele carriers vs non-carriers
- Outcome
- Association of the rs324420 variant with obesity and related traits
Methodological details645 eligible studies identified; 28 included after screening and full-text evaluation
- 645 eligible studies identified; 28 included after screening and full-text evaluation
Pooled result
As reported in the abstract
Obesity-related traits
- Some evidence of associations between the variant allele and higher BMI, waist circumference, fat mass and WHR and alterations in glucose and lipid homeostasis
- Many included studies did not report a significant difference between genotypes
Original publication
Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review. Int J Obes (Lond). Published 19 December 2023. doi:10.
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