The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials
Authors' conclusion
This meta-analysis showed that resveratrol supplementation did not significantly impact most anthropometric measures and serum leptin and adiponectin in individuals with overweight and obesity. However, it led to a significant reduction in waist circumference. The
Study context
- Population
- Individuals with overweight and obesity; Randomized controlled trials (RCTs) from Scopus, Web of Science and PubMed up to September 2025
- Participants
- 1,005 individuals23 RCTs
- Comparison
- Resveratrol supplementation vs control
- Outcome
- Anthropometric indices, adiponectin and leptin
Methodological detailsgraded
- Graded
Pooled result
As reported in the abstract
- Resveratrol
- WMD body weight −1.42 kg (95% CI −3.19 to 0.35); P = 0.117
- Resveratrol
- WMD body mass index (BMI) −0.47 kg/m² (95% CI −0.96 to 0.01); P = 0.055
- Resveratrol
- WMD fat mass 0.47 kg (95% CI −1.75 to 2.69); P = 0.679
- Resveratrol
- WMD body fat percentage −0.88 % (95% CI −1.91 to 0.15); P = 0.094
- Resveratrol
- WMD fat-free mass 1.42 kg (95% CI −1.04 to 3.89); P = 0.257
- Resveratrol
- WMD waist-hip ratio (WHR) −0.00 (95% CI −0.01 to 0.00); P = 0.436
- Resveratrol
- WMD adiponectin 1.84 µg/mL (95% CI −2.25 to 5.95); P = 0.378
- Resveratrol
- WMD leptin 1.87 ng/mL (95% CI −3.84 to 7.60); P = 0.521
- Resveratrol
- WMD waist circumference −1.93 cm (95% CI −3.10 to −0.76); P = 0.001
Further pooled results
Subgroup analyses
- Significant reductions in body weight and BMI with doses <1000 mg/day, longer interventions (≥12 weeks), and in females
- Fat-free mass (FFM) increased significantly among participants aged <50 years
- Leptin significantly elevated in both sexes
Original publication
The effect of resveratrol supplementation on anthropometric indices, adiponectin and leptin levels in individuals with overweight and obesity: a graded, systematic review and meta-analysis of randomized controlled trials. Int J Obes (Lond). Published 27 December 2025. doi:10.
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