Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics
Authors' conclusion
The metabolic disturbances show a significant progression from overweight to obesity in children, and different metabolic characteristics were demonstrated in age stratifications. The changes in the levels of phenylalanine, tyrosine, glutamine, leucine, histidine, and ascorbate were tracked with the persistence of childhood obesity. These findings will promote the mechanistic understanding of childhood overweight and obesity.
Study context
- Population
- Children with overweight and obesity defined by BMI percentile
- Participants
- 473 children
- Comparison
- Children with overweight and obesity, stratified by age
- Outcome
- Potential metabolic biomarkers identified by 1H-NMR metabolomics
Methodological details1H-NMR-based metabolomics, pattern recognition methods, age-stratified (>4 years vs ≤4 years)
- 1H-NMR-based metabolomics
- Pattern recognition methods
- Age-stratified (>4 years vs ≤4 years)
Main finding
As reported in the abstract
- Potential biomarkers related to overweight, younger (≤4 years) and older (>4 years) children, respectively
- Four and sixteen
- Potential biomarkers related to obesity, younger and older children, respectively
- two and twenty
Original publication
Childhood overweight and obesity: age stratification contributes to the differences in metabolic characteristics. Obesity (Silver Spring). Published 19 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →