Lipids & metabolic liver disease
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography
Main finding · Incident LVDDResult — go to the resultAdjusted hazard ratio 1.21 95 % CI 1.02–1.43Authors' conclusion
This study demonstrated that NAFLD was associated with an increased risk of LVDD in a large cohort. More severe forms of hepatic steatosis and/or significant liver fibrosis may increase the risk of developing LVDD.
Study context
- Population
- Adults from a medical health check-up program; 7-year follow-up
- Participants
- 3,380 adults
- Exposure
- Nonalcoholic fatty liver disease (NAFLD) vs no NAFLD
- Outcome
- Incident LVDD, by serial echocardiography
Methodological detailsserial echocardiography, parametric Cox proportional hazards model
- Serial echocardiography
- Parametric Cox proportional hazards model
Main finding
Incident LVDD
Adjusted hazard ratio
1.21
95 % CI 1.02–1.43
NAFLDvs Without NAFLD
aHR 1.21 (95 % CI 1.02–1.43)
As reported in the abstract
- Incident left ventricular diastolic dysfunction (LVDD) cases (all subjects), 11,327 person-years
- 560 (16.0 %)
Observational data: associations, not effects.
Further findings
| Outcome | multivariable-aHR (95 % CI) | P value | |
|---|---|---|---|
| LVDD by APRI fibrosis categoryAPRI < 0.5vs Without NAFLD | 1.20 (1.01–1.42) | P = 0.036 | |
| LVDD by APRI fibrosis categoryAPRI ≥ 0.5vs Without NAFLD | 1.36 (0.90–2.06) | P = 0.036 | |
| 0.512Multivariable-aHR (log scale) |
LVDD by degree of hepatic steatosis
- Risk of LVDD increased progressively with increasing degree of hepatic steatosis
- P < 0.001
LVDD by APRI fibrosis category
- NAFLD fibrosis score (NFS) and FIB-4 index showed insignificant results
Original publication
Association between nonalcoholic fatty liver disease and left ventricular diastolic dysfunction: A 7-year retrospective cohort study of 3,380 adults using serial echocardiography. Diabetes Metab. Published 10 April 2024. doi:10.
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