Lipids & metabolic liver disease
Association of physical activity and sports participation with insulin resistance and non‐alcoholic fatty liver disease in people with type 1 diabetes
Authors' conclusion
In our T1D population, we could not find any dose-dependent association between PA, insulin resistance and NAFLD. People participating in sports had a lower degree of insulin resistance and lower odds for NAFLD.
Study context
- Population
- People with T1D from a secondary and tertiary care centre; men 56%, age 44 ± 14 years, diabetes duration 24 ± 14 years, median BMI 24.8 kg/m²150 underwent transient elastography (TE)
- Participants
- 254 people
- Exposure
- Physical activity and sports participation vs insulin resistance and non-alcoholic fatty liver disease (NAFLD)
- Outcome
- Association of questionnaire-derived PA (METh/week) and sports participation with insulin resistance (eGDR) and NAFLD (transient elastography)
Methodological detailssecondary and tertiary care centre, adjusted for age, sex, diabetes duration and BMI
- Secondary and tertiary care centre
- Adjusted for age, sex, diabetes duration and BMI
Main finding
As reported in the abstract
Association of PA and sports participation with eGDR and NAFLD
- Total physical activity (PA), median METh/week
- 50.7
- Estimated glucose disposal rate (eGDR), median mg/kg/min
- 7.31
- Total PA vs eGDR: beta (95% CI), not significant
- −0.00 (−0.01 to 0.00)
- Total PA vs NAFLD: OR (95% CI), not significant
- 1.00 (0.99-1.01)
- Sports participation vs eGDR: beta (95% CI), significant
- 0.94 (0.48-1.41)
- Sports participation vs NAFLD: OR (95% CI), significant
- 0.21 (0.08-0.56)
Observational data: associations, not effects.
Original publication
Association of physical activity and sports participation with insulin resistance and non‐alcoholic fatty liver disease in people with type 1 diabetes. Diabet Med. Published 8 April 2024. doi:10.
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