Lipids & metabolic liver disease
Diagnostic performance of the GGT/high-density lipoprotein cholesterol (HDL-C) ratio for non-alcoholic fatty liver disease (NAFLD) in adults with obesity undergoing bariatric surgery
Authors' conclusion
The GGT/HDL-C ratio is a promising biomarker for the diagnosis of NAFLD in an adult population living with obesity.
Study context
- Population
- Adults with obesity undergoing bariatric surgery
- Participants
- 249 adults
- Exposure
- GGT/HDL-C ratio for diagnosis of NAFLD
- Outcome
- Diagnostic performance of the GGT/HDL-C ratio for NAFLD
Methodological detailsanalytical, diagnostic test evaluation, secondary database
- Analytical
- Diagnostic test evaluation
- Secondary database
Main finding
As reported in the abstract
Diagnostic performance for NAFLD
| Group | Optimal cut-off | AUC | Sensitivity | Specificity |
|---|---|---|---|---|
| GGT/HDL-C ratio | 20.5 U/mmol | 0.81 (95% CI: 0.64-0.98) | 82.5% | 77.8% |
GGT/HDL-C ratio
Optimal cut-off20.5 U/mmol
AUC0.81 (95% CI: 0.64-0.98)
Sensitivity82.5%
Specificity77.8%
Observational data: associations, not effects.
Further findings
| Outcome | PR (95% CI) | |
|---|---|---|
| Prevalence of NAFLD with elevatedvs normal GGT/HDL-C ratio, overallPrevalence increased by 14% | 1.14 (1.04–1.33) | |
| Prevalence of NAFLD with elevatedvs normal GGT/HDL-C ratio, women19% increased prevalence | 1.19 (1.07–1.42) | |
| 0.512Prevalence ratio (log scale) |
Original publication
Diagnostic performance of the GGT/HDL-C ratio for NAFLD in adults with obesity undergoing bariatric surgery. Diabetes Res Clin Pract. Published 3 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →