Association between neutrophil/lymphocyte ratio and kidney impairment in type 2 diabetes mellitus: A role of extracellular water/total body water ratio
Authors' conclusion
Increased NLR reflecting systemic inflammation is associated with progressive kidney function decline in T2DM, partially explained by dysregulated body fluid balance.
Study context
- Population
- Adults with T2D, single centre
- Participants
- 1,224 adults
- Exposure
- Baseline neutrophil/lymphocyte ratio (NLR) and kidney outcomes
- Outcome
- Progressive kidney function decline or albuminuria progression
- Follow-up
- median 2-year follow-up
Methodological detailslongitudinal, single-centre, mediation analysis
- Longitudinal
- Single-centre
- Mediation analysis
Main finding
As reported in the abstract
NLR and progressive kidney function decline, HR
1.39
95% CI 1.21–1.60P < 0.001
NLR and albuminuria progression, HR
1.34
95% CI 1.08–1.68P = 0.009
Observational data: associations, not effects.
Further findings
Risk discrimination (Harrell's C) on adding NLR to base model
- Significantly improved discrimination of kidney function decline, P = 0.022
- No improvement for albuminuria progression
Mediation by ECW/TBW ratio
- Share of total effect between NLR and kidney function loss explained by ECW/TBW ratio
- 19.7%
Original publication
Association between neutrophil/lymphocyte ratio and kidney impairment in type 2 diabetes mellitus: A role of extracellular water/total body water ratio. Diabetes Res Clin Pract. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →