Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study
Authors' conclusion
NAFLD was associated with a higher risk of type 2 diabetes among White participants but not among Black participants. This finding suggests that the effect of liver fat on impaired glucose metabolism may be smaller in Black than in White individuals.
Study context
- Population
- Non-Asian adults without T2D at baseline in the CARDIA study; mean age 50.0±3.6 years, 59% women, 55.0% White, 45.0% Black
- Participants
- 1,995 adults
- Exposure
- Non-alcoholic fatty liver disease (NAFLD) vs no NAFLD, by race
- Outcome
- Incident T2D
- Follow-up
- Exam (2015-2016)
Methodological detailstargeted maximum likelihood estimation with machine-learning algorithms, multivariable adjustment
- Targeted maximum likelihood estimation with machine-learning algorithms
- Multivariable adjustment
Main finding
As reported in the abstract
Risk difference for T2D by race · follow-up (2015-2016)
Each group vs no NAFLDEstimate (95% CI)
NAFLD
risk difference (White participants) 4.1%(0.3%–7.9%)
NAFLD
risk difference (Black participants) −1.9%(−5.7% to 2.0%)
Observational data: associations, not effects.
Further findings
NAFLD prevalence at baseline, by race
Incident T2D, by race · follow up
Original publication
Racial difference in the association between non-alcoholic fatty liver disease and incident type 2 diabetes: findings from the CARDIA study. Diabetologia. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →