Association Between Mixed Exposure to Dioxins and Dioxin-Like Polychlorinated Biphenyls and Obesity Among US Adults
Authors' conclusion
Our findings revealed that mixed exposure to dioxins and DL-PCBs is positively correlated with obesity.
Study context
- Population
- US adults, National Health and Nutrition Examination Survey 2003–2004; 9 kinds of dioxins and DL-PCBs measured
- Participants
- 852 adults
- Exposure
- Exposure to dioxins and DL-PCBs and obesity
- Outcome
- Obesity
Methodological detailsgeneralized linear regression, weighted quantile sum (WQS) regression, Bayesian kernel machine regression (BKMR), mediation analysis
- Generalized linear regression
- Weighted quantile sum (WQS) regression
- Bayesian kernel machine regression (BKMR)
- Mediation analysis
Main finding
As reported in the abstract
- Dioxins and DL-PCBs were risk factors for obesity in logistic regression models
- WQS and BKMR regression: combined exposure to dioxins and DL-PCBs linked to obesity; the hepta-chlorinated dibenzo-p-dioxin (hpcdd) showed the greatest contributions
Observational data: associations, not effects.
Further findings
Mediation by hemoglobin A1c (HbA1c) of dioxins' relationships with obesity or obesity indices
- Proportion mediated by HbA1c
- 5.21% to 9.04%
- Beta estimates
- 0.007 (0.002, 0.010), 0.007 (0.0005, 0.020), 0.380 (0.133, 0.800), 0.408 (0.132, 0.800) (95% CI)
Original publication
Association Between Mixed Exposure to Dioxins and Dioxin-Like Polychlorinated Biphenyls and Obesity Among US Adults. J Clin Endocrinol Metab. Published 16 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →