Association between body roundness index and chronic kidney disease risk in patients with diabetes: A cross-sectional analysis of NHANES 1999–2018
Authors' conclusion
BRI is an independent marker of CKD risk in individuals with diabetes and may reflect contributions from glycaemic control, kidney function, and nutritional status. It may serve as a practical tool for CKD risk stratification.
Study context
- Population
- Individuals with diabetes, NHANES 1999–2018
- Participants
- 6,971 individuals
- Exposure
- Per-unit increase in Body Roundness Index (BRI)
- Outcome
- CKD (eGFR < 60 mL/min/1.73 m² or ACR ≥ 30 mg/g)
Methodological detailsNHANES 1999–2018, weighted multivariable logistic regression
- NHANES 1999–2018
- Weighted multivariable logistic regression
Main finding
As reported in the abstract
CKD per unit increase in BRI
OR for chronic kidney disease (CKD) per unit increase in BRI, fully adjusted
1.109
95% CI 1.040–1.183p = 0.002
Higher odds of CKD per unit increase in BRI
10.5 %
Observational data: associations, not effects.
Further findings
Subgroups
- Stronger associations in males, younger individuals, and those with elevated blood pressure or uric acid
- Inverse association in participants with severe proteinuria
Mediation analysis (proportion mediated)
%
- HbA1c
- 3.9
- Serum creatinine
- 27.7
- Albumin
- −26.2
- Partial effects
Original publication
Association between body roundness index and chronic kidney disease risk in patients with diabetes: A cross-sectional analysis of NHANES 1999–2018. Diabetes Res Clin Pract. Published 21 May 2025. doi:10.
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