Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study
Authors' conclusion
In this population-based cohort study, a younger age at diagnosis of type 2 diabetes was associated with a higher relative risk of mortality and CVD outcomes. Therefore, primary prevention of type 2 diabetes is desirable at all ages but is particularly important at younger ages.
Study context
- Population
- Patients with newly diagnosed T2D between January 1, 2012, and December 31, 2014, Korean population cohort, with nondiabetic matched controlsT2D patients
- Participants
- 634,350 patients
- Exposure
- T2D diagnosed at ≤40 years vs nondiabetic matched controls
- Outcome
- Total mortality, HF hospitalization and coronary heart disease by age at diagnosis
- Follow-up
- 5.7 years
Methodological detailsnationwide, matched controls 1:2, Followed until the end of 2019 for CVD outcomes and mortality
- Nationwide
- Matched controls 1:2
- Followed until the end of 2019 for CVD outcomes and mortality
Main finding
As reported in the abstract
Each group vs controlsEstimate (95 % CI)
T2D diagnosed ≤40 years
aHR (total mortality) 6.08(5.51–6.70)
T2D diagnosed ≤40 years
aHR (hospitalization for HF) 7.10(6.66–7.58)
T2D diagnosed ≤40 years
aHR (coronary heart disease) 5.04(4.86–5.24)
Observational data: associations, not effects.
Original publication
Association between age at diagnosis of type 2 diabetes and cardiovascular morbidity and mortality risks: A nationwide population-based study. Diabetes Res Clin Pract. Published 17 January 2024. doi:10.
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