Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the China Health and Retirement Longitudinal Study (CHARLS) and English Longitudinal Study of Ageing (ELSA) aging cohorts
Authors' conclusion
CumTyG-BRI may be a relatively robust TyG-related indicator for predicting new-onset CVD across cohorts, with low heterogeneity and an approximately linear association. Hypertension may partly mediate this association. The online tool may support preliminary CVD risk stratification, but further validation is needed before routine clinical use.
Study context
- Population
- Middle-aged and older adults from CHARLS and ELSA; follow-up from 2015 (CHARLS) and 2008 (ELSA)CHARLS and ELSA
- Participants
- 5,028 participants
- Exposure
- 14 TyG-related indices and new-onset cardiovascular disease (CVD)
- Outcome
- New-onset CVD
- Follow-up
- Median 5.0 years in CHARLS and 13.5 years in ELSA
Methodological detailstwo national aging cohorts (CHARLS and ELSA), random-effects meta-analysis, restricted cubic splines, mediation analyses
- Two national aging cohorts (CHARLS and ELSA)
- Random-effects meta-analysis
- Restricted cubic splines
- Mediation analyses
Main finding
As reported in the abstract
Incident CVD events
1,067
CumTyG-BRI Q4 vs Q1, HR
1.54 (1.27-1.86) (95% CI)
CumTyG-BRI between-cohort heterogeneity I²
6.6%
Observational data: associations, not effects.
Further findings
Dose-response (restricted cubic splines (RCS))
- Nonlinear associations for TyG-BMI and cumTyG-BMI; approximately linear for other indices
Mediation by hypertension of CumTyG-BRI–CVD association
- Proportion of total effect mediated by hypertension
- 20.6%
TyG-BRI-based nomogram for 5-year CVD risk
- C-index (moderate discrimination)
- 0.679
- Deployed as online tool
Original publication
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